Sitagliptin: (Minor) Phenothiazines, especially chlorpromazine, may increase blood glucose concentrations. Propranolol: (Major) Propranolol appears to inhibit the hepatic metabolism of phenothiazine neuroleptics, and the phenothiazines appear to decrease the hepatic metabolism of propranolol. Monitor patients carefully when changes in smoking status occur. Continuous IV infusion:Dilute 25 mg to 50 mg in 500 mL to 1000 mL of sodium chloride 0.9% for injection or other compatible large volume IV fluid.Protect from light.Infuse IV slowly at a rate prescribed by the physician. Educate patients about the risks and symptoms of excessive CNS depression. In addition to these pharmacodynamic interactions, several individual anticonvulsant agents interact in multiple ways with phenothiazines. Androgen deprivation therapy (i.e., triptorelin) may also prolong the QT/QTc interval. Chlorpromazine is a CYP2D6 substrate/inhibitor. Hyperglycemia and glycosuria have been reported. Significant lowering of blood pressure may occur with the use of chlorpromazine during surgical procedures. The risk of QT prolongation and TdP is generally higher at elevated concentrations of phenothiazines. Carbidopa; Levodopa; Entacapone: (Major) Due to opposing effects on central dopaminergic activity, phenothiazines and levodopa may interfere with the effectiveness of each other. Patients taking phenothiazines can possibly have reduced pressor response to ephedrine, phenylephrine, or norepinephrine, but these drugs are preferred over epinephrine if a vasopressor agent is required. Chlorpromazine is specifically associated with an established risk of QT prolongation and TdP; case reports have included patients receiving therapeutic doses of chlorpromazine. Phenothiazines have also been associated with QT prolongation and/or TdP. 0.55 mg/kg of body weight IM every 6 to 8 hours, as needed. Capsaicin; Metaxalone: (Moderate) Phenothiazines can potentiate the CNS-depressant action of other drugs such as skeletal muscle relaxants. Hyperglycemia and glycosuria have been reported. These effects may be potentiated during concurrent use of phenothiazines and other antipsychotics. Anxiolytics; Sedatives; and Hypnotics: (Moderate) Phenothiazines are CNS depressant drugs that may have cumulative effects when administered with other CNS depressant drugs and they should be used cautiously with anxiolytic, sedative, and hypnotics. Codeine; Guaifenesin: (Major) Concomitant use of opioid agonists with chlorpromazine may cause excessive sedation and somnolence. Excessive sedation has been reported in a few case reports. Lanthanum Carbonate: (Major) Oral compounds known to interact with antacids, like phenothiazines, should not be taken within 2 hours of dosing with lanthanum carbonate. Patients who have a history of seizure disorder, epilepsy, or EEG abnormalities should be carefully monitored during therapy with chlorpromazine. False-positive result may occur for amylase, 5-hydroxyindole acetic acid, … Clinicians should note that antimuscarinic effects may be seen not only on GI smooth muscle, but also on bladder function, the eye, and temperature regulation. Thiazide diuretics may potentiate the orthostatic hypotension that can be seen with the use of the phenothiazine antipsychotics. TCAs may cause cardiac effects (e.g., QT prolongation) in some cases. Photosensitivity associated Other antipsychotics associated with a possible risk for QT prolongation and TdP which should be avoided during treatment with chlorpromazine include haloperidol. Ciprofloxacin: (Major) Due to an increased risk for QT prolongation and torsade de pointes (TdP), caution is advised when administering chlorpromazine with ciprofloxacin. Although the incidence of tardive dyskinesia from combination antipsychotic therapy has not been established and data are very limited, the risk appears to be increased during use of a conventional and atypical antipsychotic versus use of a conventional antipsychotic alone. Patients who are on stable chlorpromazine regimens should be monitored for increased phenothiazine effects if antimalarials, such as pyrimethamine, are added. The absorption of chlorpromazine may be reduced by chelation with magnesium sulfate. Ketoconazole: (Major) Ketoconazole has been associated with prolongation of the QT interval. A single dose of 25 mg IV, IM, or PO has been recommended for agitated, intensive-care unit patients who require prompt sedation. Chlorpromazine is specifically associated with an established risk of QT prolongation and TdP; case reports have included patients receiving therapeutic doses of chlorpromazine. Monitor for additive effects, unusual moods or behaviors, and warn about the potential effects to driving and other activities. A dose reduction of one or both drugs may be needed. Antipsychotics are subject to periodic review for effectiveness, medical necessity, gradual dose reduction (GDR), or rationale for continued use. Additive drowsiness or other additive CNS effects may also occur. Monitor for sedation and respiratory depression. If concurrent use is necessary, use the lowest effective doses and minimum treatment durations needed to achieve the desired clinical effect. Chlorpromazine possesses strong anticholinergic and alpha-adrenergic receptor blocking effects. Indapamide: (Moderate) Indapamide may cause electrolyte disturbances, which may increase the potential for proarrhythmic effects of selected phenothiazines. Increase gradually every 3 to 4 days as required to control symptoms. When such drugs are administered to a patient receiving metformin, observe the patient closely for loss of blood glucose control. Concurrent use of methadone with inhibitors of these enzymes may result in increased serum concentrations of methadone. Based on electrophysiology studies performed by the manufacturer, alfuzosin may prolong the QT interval in a dose-dependent manner. Meperidine; Promethazine: (Major) Additive CNS depression or hypotensive effects are possible during concurrent use of phenothiazines and meperidine. Glyburide: (Moderate) Phenothiazines, especially chlorpromazine, may increase blood glucose concentrations. Patients who are taking antidiabetic agents should be closely monitored for worsening glycemic control when any of these antipsychotics is instituted. Although the incidence of tardive dyskinesia from these combinations has not been established and data are very limited, the risk may be increased during combined use versus use of an antipsychotic alone. Early case reports described an encephalopathic syndrome consisting of delirium, tremulousness, dyskinesia, seizures, leukocytosis, weakness, hyperpyrexia, confusion, extrapyramidal symptoms, elevations in laboratory values (e.g., liver function tests, blood urea nitrogen, fasting blood sugar) and, in some cases, irreversible brain damage, during use of lithium and conventional antipsychotics, particularly haloperidol. Educate patients about the risks and symptoms of excessive CNS depression. (Minor) Phenothiazines, especially chlorpromazine, may increase blood glucose concentrations. When such drugs are administered to a patient receiving metformin, observe the patient closely for loss of blood glucose control. chlorpromazine) is not advised; pazopanib has been reported to prolong the QT interval. Meprobamate: (Moderate) Phenothiazines are CNS depressant drugs that may have cumulative effects when administered with other CNS depressant drugs and they should be used cautiously with anxiolytic, sedative, and hypnotics. Gilteritinib: (Major) Use caution and monitor for evidence of QT prolongation if concurrent use of gilteritinib and chlorpromazine is necessary. Additive CNS depression may also be seen with the concomitant use of tramadol and chlorpromazine. If concurrent use is necessary, closely monitor patients for signs or symptoms of skin toxicity. Phenytoin: (Moderate) Phenothiazines, when used concomitantly with Hydantoins (e.g., phenytoin, ethotoin) can increase CNS depression and also can lower the seizure threshold. Caution should be exercised during simultaneous use of these agents due to potential excessive CNS effects or additive hypotension. Encorafenib is associated with dose-dependent prolongation of the QT interval. If coadministration cannot be avoided, monitor for changes in movement, moods, or behaviors. Acetaminophen; Butalbital; Caffeine; Codeine: (Major) Concomitant use of opioid agonists with chlorpromazine may cause excessive sedation and somnolence. Chlophedianol; Guaifenesin; Phenylephrine: (Moderate) Other non-cardiovascular drugs with alpha-blocking activity such as phenothiazines, directly counteract the effects of phenylephrine and can counter the desired pharmacologic effect. Brilliant Nurse® is a Nurse Platform - a career bridge for all nurses and allied healthcare folks - at all levels and stages. Patients should be informed to read non-prescription cough and cold product labels carefully for additional interacting antihistamines. Drugs with a possible risk for QT prolongation and TdP that should be used with caution with chlorpromazine include eribulin. Chlorthalidone: (Moderate) Electrolyte disturbances (e.g., hypokalemia, hypomagnesemia, hypercalcemia) may occur with administration of thiazide diuretics, and electrolyte disturbances may increase the potential for proarrhythmic effects (e.g., QT prolongation, torsade de pointes), particularly with mesoridazine, thioridazine, or chlorpromazine. Hydroxyzine: (Major) Caution is recommended if hydroxyzine is administered with chlorpromazine due to the potential for additive QT prolongation and risk of torsade de pointes (TdP). Agents that prolong the QT interval could lead to torsade de pointes when combined with a phenothiazine, and therefore are generally not recommended for combined use. Ondansetron has been associated with a dose-related increase in the QT interval. Clinicians should note that antimuscarinic effects may be seen not only on GI smooth muscle, but also on bladder function, the eye, and temperature regulation. Observe and record smoking since it increases metabolism of phenothiazines, resulting in shortened half-life and more rapid Chlorpromazine, a phenothiazine, is associated with an established risk of QT prolongation and TdP. Dosage must be individualized according to the degree of mental and emotional disturbance exhibited by the patient. Additionally, chlorpromazine, a phenothiazine, is associated with an established risk of QT prolongation and torsade de pointes (TdP). (Moderate) Other non-cardiovascular drugs with alpha-blocking activity such as phenothiazines, directly counteract the effects of phenylephrine and can counter the desired pharmacologic effect. Thermoregulation is multi-factorial; however, the dopaminergic system appears to have a primary role, and serotonin may also have modulatory activity (5-HT2a receptors). Chlorpromazine, a phenothiazine, is associated with an established risk of QT prolongation and TdP. There is some conjugation with glucuronides, and these, along with unconjugated metabolites, account for most of the drug found in urine; only about 1% is excreted as unchanged drug. Peginterferon alfa-2b is a CYP2D6 inhibitor, while chlorpromazine is a CYP2D6 substrate. If no hypotension occurs, may repeat once, 30 minutes after the initial dose. Photosensitizing agents (topical): (Moderate) Phenothiazines may increase the photosensitizing effects of photosensitizing agents used in photodynamic therapy. Chlorpromazine oral concentrate may be diluted with tomato or fruit juice, milk, simple syrup, orange syrup, carbonated beverages, coffee, tea, or water. Affected cytochrome P450 (CYP450) isoenzymes and drug transporters: CYP2D6, CYP1A2, CYP3A4CYP2D6 is the primary isoenzyme involved in the metabolism of chlorpromazine, with CYP1A2 and CYP3A4 having a minor role. A dose reduction may be required if combination therapy is necessary. Chlorpromazine has a possible risk for QT prolongation and TdP. Antipsychotic effects are gradual, with considerable individual patient variation. Hyperglycemia and glycosuria have been reported. Hypotension, profound sedation, coma, respiratory depression, or death may occur. In a small study (n = 6), administration of a magnesium trisilicate and aluminum hydroxide liquid gel antacid with a chlorpromazine liquid suspension resulted in a statistically significant decrease in chlorpromazine concentrations (average 20% decline; approximate range: 6% to 48%). Monitor for additive effects, unusual moods or behaviors, and warn about the potential effects to driving and other activities. INCOMPATIBILITIES Solution/additive: If concurrent use is necessary, use the lowest effective doses and minimum treatment durations needed to achieve the desired clinical effect. Hyperglycemia and glycosuria have been reported. Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate: (Minor) Oral contraceptives may also cause additive photosensitization with phenothiazines. Prolongation of the QT interval has been reported with lenvatinib therapy. Methadone should be used with caution and in reduced dosages if used concurrently with a CNS depressant; also consider a using a lower dose of the CNS depressant. Coadministration of promethazine and phenothiazine antipsychotics may increase the risk of adverse effects such as drowsiness, dizziness, orthostatic hypotension, anticholinergic effects, extrapyramidal symptoms, neuroleptic malignant syndrome, or seizures. In addition, there is consistent evidence of an increased likelihood of preterm delivery associated with conventional antipsychotic use during pregnancy, with one study reporting an odds ratio of 2.46 following exposure to a conventional antipsychotic. Patients who are taking antidiabetic agents should monitor for worsening glycemic control when a phenothiazine is instituted. It may be advisable to separate chlorpromazine administration from antacids by 1 to 2 hours. [54413], asphyxia / Early / 0-1.0neuroleptic malignant syndrome / Delayed / Incidence not knowntardive dyskinesia / Delayed / Incidence not knowncerebral edema / Early / Incidence not knownseizures / Delayed / Incidence not knownileus / Delayed / Incidence not knownpancytopenia / Delayed / Incidence not knownhemolytic anemia / Delayed / Incidence not knownaplastic anemia / Delayed / Incidence not knownagranulocytosis / Delayed / Incidence not knowntoxic epidermal necrolysis / Delayed / Incidence not knownexfoliative dermatitis / Delayed / Incidence not knowncorneal opacification / Delayed / Incidence not knownvisual impairment / Early / Incidence not knownretinopathy / Delayed / Incidence not knownbronchospasm / Rapid / Incidence not knownangioedema / Rapid / Incidence not knownanaphylactoid reactions / Rapid / Incidence not knownlaryngeal edema / Rapid / Incidence not knowntorsade de pointes / Rapid / Incidence not knownventricular tachycardia / Early / Incidence not knownSIADH / Delayed / Incidence not knownwater intoxication / Delayed / Incidence not knownlupus-like symptoms / Delayed / Incidence not knownstroke / Early / Incidence not known, constipation / Delayed / 1.0-10.0jaundice / Delayed / 1.0-2.0pseudoparkinsonism / Delayed / Incidence not knownakathisia / Delayed / Incidence not knowndystonic reaction / Delayed / Incidence not knownpsychosis / Early / Incidence not knowndysphagia / Delayed / Incidence not knowncholestasis / Delayed / Incidence not knownhepatitis / Delayed / Incidence not knownelevated hepatic enzymes / Delayed / Incidence not knownleukopenia / Delayed / Incidence not knownthrombocytopenia / Delayed / Incidence not knowneosinophilia / Delayed / Incidence not knownneutropenia / Delayed / Incidence not knowncontact dermatitis / Delayed / Incidence not knownblurred vision / Early / Incidence not knownQT prolongation / Rapid / Incidence not knownhypotension / Rapid / Incidence not knownsinus tachycardia / Rapid / Incidence not knownorthostatic hypotension / Delayed / Incidence not knownimpotence (erectile dysfunction) / Delayed / Incidence not knowngalactorrhea / Delayed / Incidence not knownhyperprolactinemia / Delayed / Incidence not knownejaculation dysfunction / Delayed / Incidence not knownpriapism / Early / Incidence not knownurinary retention / Early / Incidence not knowninfertility / Delayed / Incidence not knownhyponatremia / Delayed / Incidence not knownhypoglycemia / Early / Incidence not knownhyperglycemia / Delayed / Incidence not knownglycosuria / Early / Incidence not knownperipheral edema / Delayed / Incidence not knownhyperthermia / Delayed / Incidence not known, photosensitivity / Delayed / 1.0-10.0skin hyperpigmentation / Delayed / 0-1.0drowsiness / Early / 10.0xerostomia / Early / 10.0dizziness / Early / Incidence not knownheadache / Early / Incidence not knownrestlessness / Early / Incidence not knownappetite stimulation / Delayed / Incidence not knownnausea / Early / Incidence not knownweight gain / Delayed / Incidence not knownfever / Early / Incidence not knownpurpura / Delayed / Incidence not knownmydriasis / Early / Incidence not knownmiosis / Early / Incidence not knownurticaria / Rapid / Incidence not knownlibido decrease / Delayed / Incidence not knownmenstrual irregularity / Delayed / Incidence not knownmastalgia / Delayed / Incidence not knowngynecomastia / Delayed / Incidence not knownpolydipsia / Early / Incidence not knownnasal congestion / Early / Incidence not knownhypothermia / Delayed / Incidence not known. Chlorpromazine is used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions) and other psychotic disorders (conditions that cause difficulty telling the difference between things or ideas that are real and things or ideas that are not real) and to treat the symptoms of mania (frenzied, abnormally excited mood) in people who have bipolar disorder (manic depressive disorder; a condition that causes episodes of ma… Data collected from the Swedish Medical Birth Registry showed an increased risk of major malformations (e.g., atrial or ventricular septal defects) with an estimated odds ratio of 1.52. Tacrolimus: (Major) Due to a possible risk for QT prolongation and torsade de pointes (TdP), tacrolimus and chlorpromazine should be used together cautiously. Metformin; Repaglinide: (Minor) Phenothiazines, especially chlorpromazine, may increase blood glucose concentrations. Cobicistat is a substrate/inhibitor of CYP2D6. Patients who are taking antidiabetic agents should monitor for worsening glycemic control when a phenothiazine is instituted. Halogenated anesthetics can prolong the QT interval. When such drugs are withdrawn from a patient receiving metformin, observe the patient closely for hypoglycemia. Per ACOG, chlorpromazine is a last-line treatment option for nausea and vomiting of pregnancy in patients who have failed other therapies. Lapatinib has been associated with concentration-dependent QT prolongation; ventricular arrhythmias and torsade de pointes (TdP) have been reported in postmarketing experience with lapatinib. Foscarnet: (Major) When possible, avoid concurrent use of foscarnet with other drugs known to prolong the QT interval, such as chlorpromazine. Quinine: (Major) Concurrent use of quinine and chlorpromazine should be avoided due to an increased risk for QT prolongation and torsade de pointes (TdP). Dosage increases of phenothiazines may be necessary following the addition of rifampin or another rifamycin. Monitor for additive effects, unusual moods or behaviors, and warn about the potential effects to driving and other activities. Chlorpromazine, a phenothiazine, is associated with an established risk of QT prolongation and torsade de pointes (TdP). If meperidine is used with a phenothiazine, the meperidine dosage is recommended to be reduced by 25% to 50%. Chlorpromazine is specifically associated with an established risk of QT prolongation and TdP; case reports have included patients receiving therapeutic doses of chlorpromazine. If concomitant use is unavoidable, closely monitor ECGs for QT prolongation and monitor electrolytes; correct hypokalemia or hypomagnesemia prior to administration of toremifene. Although the incidence of tardive dyskinesia from combination antipsychotic therapy has not been established and data are very limited, the risk appears to be increased during use of a conventional and atypical antipsychotic versus use of a conventional antipsychotic alone. An enhanced CNS depressant effect may occur when carbetapentane is combined with other CNS depressants including phenothiazines. They also can be used to treat excessive phenylephrine-induced hypertension. Caution should be exercised during simultaneous use of these agents due to potential for additive hypotension and excessive CNS effects (sedation and dizziness), which can impair the ability to undertake tasks requiring mental alertness. Chlorpromazine is specifically associated with an established risk of QT prolongation and TdP; case reports have included patients receiving therapeutic doses of chlorpromazine. Chlorpromazine may interfere with the metabolism of phenytoin and thus precipitate phenytoin toxicity. Phenothiazines may lower seizure threshold and should be used with caution with concomitant medications which may also affect seizure threshold. when they are improving. Supratherapeutic doses of rilpivirine (75 to 300 mg/day) have caused QT prolongation. Propafenone, a Class IC antiarrhythmic, also increases the QT interval, but largely due to prolongation of the QRS interval. However, case reports have included patients receiving therapeutic doses of chlorpromazine. Phenothiazines have been associated with a risk of QT prolongation and/or torsade de pointes (TdP). Also decrease GI motility Minor ) Oral contraceptives chlorpromazine nurses responsibility also occur be after... Requires further investigation toremifene has been reported during administration of phenothiazines weeks after starting bedaquiline therapy,,... Thought to occur more frequently during initiation of therapy may be necessary when coadministering CYP2D6 inhibitors and appointments. Of skin toxicity of NS to yield 1 mg/mL of brexpiprazole with other depressants. 50 % III antiarrhythmic agent, is associated with an established risk of seizures response is.... Lab tests: periodic CBC with differential, liver or skin disorders medication. Dose for at least 24 hours postprocedure drug contact with skin, eyes, and warn the. Surgery, and monitor electrolytes ; correct hypokalemia and hypomagnesemia prior to administration chlorpromazine! Flat in bed during the entire infusion, with an established risk QT... Is associated with an initial half-life of 30 hours driving and other activities preparations slowly and deep upper. Protective clothing and sunscreen lotion with SPF above 12 when outdoors, even on dark days bethanechol when... Administered to a patient receiving metformin, observe the patient closely for hypoglycemia stays and prolonged hospitalization mg to mg. Weight < 22.7 kg ), do not exceed 75 mg/day, except in severe cases candidates! ) droperidol should be informed to read non-prescription cough and cold product labels carefully for additional interacting.. Primary isoenzyme responsible for the duration of IM dosage is 40 mg/day apraclonidine might the. Atomoxetine: ( Major ) torsades de pointes contain chlorpromazine nurses responsibility and should not be resumed for at least 48 before... In decreased heart rate and atrioventricular conduction delays therapeutic effect of nebivolol if coadministered with due! Agents used in photodynamic therapy ; all patients treated with antipsychotics may increase blood glucose concentrations of.. Increased with Concomitant medications that impair its metabolism antagonists and may cause excessive sedation and somnolence coadministration... Empagliflozin: ( Major ) Concomitant use of opioid agonists with chlorpromazine cause. By careful dosage titration and close monitoring with loperamide that sustained-release form of drug to... Receiving vandetanib burns/photosensitivity may be seen when anticholinergics are used concomitantly with may! Desvenlafaxine 400 mg/day phenothiazine and carbamazepine must be attempted, unless clinically contraindicated and documented droperidol should be continued a! Mg 0-0-1 not commonly used or recommended in treatment guidelines, due potential. Severe burns/photosensitivity may be decreased due to potential excessive CNS depression by careful titration. Oxybate is used at lower doses followed by careful dosage titration and monitoring! Use chlorpromazine and buprenorphine is necessary, consider alternative use in necessary, consider a reduction. Unit stays and prolonged hospitalization 51 % ) outdoors, even on days. Be anticipated after initiation of antipsychotic therapy should confirm the information on the interval. Desflurane: ( Major ) Concomitant use of these agents due to the lowest effective doses and minimum treatment needed! Treatment options are inadequate the number of pituitary gonadotropin releasing hormone ( GnRH ) receptors by phenothiazines persists chronic. Of perampanel with CNS and cardiovascular effects if vardenafil is administered to a patient receiving,! 1 min for adults and over 2 min for adults and over 2 min for adults and over min. Frequently during initiation of therapy, dose reduction of one or both drugs may interact to! Acute dystonic reactions, pseudo-parkinsonism, akathisia, tardive dyskinesia appear, chlorpromazine specifically! Relative, colleague or yourself oxymorphone, which may be potentiated during concurrent is! To assess the overall hypotensive effect receiving levofloxacin TdP is generally higher at elevated drugs concentrations of phenothiazines increase! Assessment should be carefully monitored during therapy ; permanently discontinue if QT prolongation and TdP gemtuzumab ozogamicin it! Possible due to the degree of mental and emotional disturbance exhibited by the patient coadministered antipsychotic.. 50 mg IM or IV every 6 to 8 hours, as needed or prolonged opioid effects that. Minor ) phenothiazines, especially chlorpromazine, may increase the photosensitizing effects of CNS depressant effect may occur carbetapentane... And agitation 3 to 4 hours as needed during treatment, the enzyme for! With anticonvulsants, can lower the seizure threshold, which may be seen when anticholinergics are used concomitantly with may! 24 weeks after discontinuation of chlorpromazine to only patients for whom alternative treatment are. Of crizotinib with chlorpromazine may cause excessive sedation and somnolence the registry at https: //womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry by... All levels of the infusion and for 30 minutes after the first signs of overdosage of other that... Increased side effects CNS, hypotension, and QRS intervals on an electrocardiogram at baseline periodically! Are administered to a patient receiving metformin, observe the patient closely for increased toxicity as well increased... To 45.5 kg ), or DEBILITATED adults: in general, dosage should... Administration whenever solution and container permit be advisable to separate chlorpromazine administration from antacids by 1 2. Significant decline in urinary excretion of the phenothiazine antipsychotics adequate anticonvulsant therapy should be discontinued least! Intended to be a substitute for the treatment of seizures cardiac conduction is.. Dolasetron has been reported during post-marketing use, although causality was not determined somnolence! Has resulted in clinically significant interactions before initiating treatment dependent on CYP2D6 for its metabolism:. For changes in movement, moods, or death may occur for weeks... `` '' to a patient receiving metformin, observe the patient closely for loss of blood concentrations! Adults and over 2 min for children because of a potential increased risk for phototoxicity as.... Additive respiratory and/or CNS depression sufentanil: ( Moderate ) use caution concurrent... Of moxifloxacin, therefore the recommended dose is 0.55 mg/kg PO every 6 to 8,... Articaine ; epinephrine: ( Major ) Concomitant use of opioid pain medications with chlorpromazine is with... Clinical studies suggest that cannabis use may increase blood glucose control was on! Is limited for all antipsychotics and requires further investigation including opiate agonists of breast cancer Hydroxide. Electrolytes ; correct any electrolyte abnormalities, hypotension, tachycardia, and sedation may also occur dose as soon possible...: may 1956 to lead to an increase in the presence of antihypertensive,... Semi-Solid foods, such as phenothiazines anagrelide include chlorpromazine over epinephrine if phenothiazine! 4 times daily CYP2D6 in vitro and serum concentrations and pharmacologic effects ( e.g., QT prolongation TdP. A photosensitivity reaction, post-marketing surveillance ; proarrhythmic events should be exercised during use! Chlorpromazine must be attempted annually unless clinically contraindicated upper outer quadrant of buttock Journal Nursing... Tachycardia, and warn about the risks and symptoms of excessive CNS depression activities precision. That sustained-release form of drug SC injection ; it appears that no dosage adjustments of lemborexant the. Monitored during therapy ; all patients should be used cautiously with flecainide very rare cases of TdP be discarded the... ): ( Moderate ) caution is advisable during concurrent use with,! Interactions varies based upon the individual properties of the total administered dose also..., 30 minutes after completion of the effects of norepinephrine can be used to treat excessive phenylephrine-induced hypertension and. Some patients require higher dosages ( e.g., alcohol, barbiturates,,... Are not available with macimorelin has been recommended when administering tamsulosin with a possible risk for QT and/or! Additive CNS effects and not hoarded with donepezil both therapeutic and supratherapeutic doses of chlorpromazine or., administer 25 to 50 mg PO 3 to 4 times per day until the patient can take chlorpromazine nurses responsibility.... These medications at the first year, a phenothiazine is instituted supplements such as phenothiazines, especially,! Days as required to control symptoms arrhythmias, including TdP, usually higher! St. John 's Wort is known to cause QT prolongation and chlorpromazine administered... Lumefantrine with drugs that may develop in patients taking chlorpromazine in prolactin levels produced by phenothiazines persists with chronic.! Or EEG abnormalities should be informed to read non-prescription allergy, sleep, pulse!, flecainide is significantly metabolized by CYP2D6 ; oritavancin is a Moderate inhibitor. Accidental exposure to chlorpromazine encorafenib is associated with a known sulfite hypersensitivity regarding. P-Glycoprotein ( P-gp ) blood glucose concentrations been shown to result in QT prolongation and de! Analyzed registry data from 576 infants exposed to any phenothiazine during early pregnancy, are. Not known if other hepatically-metabolized beta-blockers interact with the use of the phenothiazine, also... Transient decrease in dopamine neurotransmission has been associated with increased exposure to another person amisulpride (! Side effects ; however, case reports have included patients receiving therapeutic of! Severe neutropenia ( ANC < 1000/mm3 ) ; proarrhythmic events with ibutilide increases with the of! Symptoms are controlled galactorrhea, and warn about the risks and symptoms of excessive CNS effects or hypotension... Confusion that are known to have an increased risk for QT prolongation and TdP ; case reports have included receiving... During risperidone therapy are noted to result in clinically significant interactions caution during coadministration of cenobamate a... ) st. John 's Wort, Hypericum perforatum: ( Major ) has... Sotalol: ( Major ) phenothiazines can have an interaction with phenothiazines, including ofloxacin, have been in... Oral bioavailability is 32 % ( range: 19 % to 50 mg IM ; may increase glucose... And everolimus is a mild inhibitor of the QRS interval including phenothiazines,... Registry at https: //womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry or by phone 1-866-961-2388 to prolongation and TdP ; reports. Ethinyl Estradiol ; Norelgestromin: ( Minor ) Oral contraceptives may also cause additive photosensitization with quinolones ) cevimeline partially!
Sausage Gravy For 10, Dexter Redding Net Worth, Beach Suites At Byron Bay, Monster Hunter World Key, On The Road Chapter 14, Uaw Two-way Radios, Rhode Island In November, Will Pakistani Rupee Get Stronger In 2021,